Further, well-designed trials with sufficient details of the contents of aloe vera products should be carried out to determine the effectiveness of aloe vera. However, cumulative evidence tends to support that aloe vera might be an effective interventions used in burn wound healing for first to second degree burns. Due to the differences of products and outcome measures, there is paucity to draw a specific conclusion regarding the effect of aloe vera for burn wound healing. Based on a meta-analysis using duration of wound healing as an outcome measure, the summary weighted mean difference in healing time of the aloe vera group was 8.79 days shorter than those in the control group (P=0.006). Four studies with a total of 371 patients were included in this review. Long-term tissue damage is rare and often consists of an increase or decrease in the skin color. The burn site is red, painful, dry, and with no blisters. Two reviewers independently extracted data on study characteristics, patient characteristics, intervention, and outcome measure. First-degree burns affect only the outer layer of skin, the epidermis. There were no restrictions on any language of publication. Only controlled clinical trials for burn healing were included. We electronically searched relevant studies in MEDLINE, CINAHL, Cochrane Library, HealthSTAR, DARE, South-East Asia Database, Chinese Databases, and several Thai local Databases (1918-June 2004). We conducted a systematic review to determine the efficacy of topical aloe vera for the treatment of burn wounds. Aloe vera has been traditionally used for burn healing but clinical evidence remains unclear.
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